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Successful Lung Transplantation From Hepatitis C Positive Donor to Seronegative Recipient
Author(s) -
Khan B.,
Singer L. G.,
Lilly L. B.,
Chaparro C.,
Martinu T.,
Juvet S.,
Pipkin M.,
Waddell T. K.,
Keshavjee S.,
Humar A.,
Cypel M.
Publication year - 2017
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14137
Subject(s) - medicine , hepatitis c , lung transplantation , transplantation , immunology , lung , liver transplantation , transmission (telecommunications) , viral hepatitis , hepacivirus , viral disease , human immunodeficiency virus (hiv) , electrical engineering , engineering
Lung transplantation using RNA + hepatitis C ( HCV +) donors to seronegative recipients is not currently performed due to the very high risk of transmission. Previous reports have shown poor survival when this practice was applied. The emergence of new direct‐acting antiviral drugs ( DAA ) suggests a high chance of sustained virologic response in immunocompetent patients. We report here successful transplantation of lungs from HCV + donor to HCV − recipient. The recipient was an HCV − patient with chronic lung allograft dysfunction. Viral transmission occurred early posttransplant but excellent clinical outcomes were observed including elimination of HCV after 12 weeks of treatment using DAA s.