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Super‐ MANF to the Rescue: Immunomodulation Improves Retinal Repair and Regenerative Cell Therapy
Author(s) -
Miller Michelle L.,
Alegre MariaLuisa
Publication year - 2017
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14120
Subject(s) - medicine , genetic enhancement , cell therapy , regenerative medicine , retinal , immunology , ophthalmology , microbiology and biotechnology , stem cell , gene , genetics , biology
Neves et al identify MANF as an evolutionarily conserved factor in Drosophila and mice that stimulates alternative activation of innate immune cells to facilitate tissue repair following retinal damage, delays congenital forms of retinal degeneration, and promotes engraftment of transplanted retinal cells, improving visual function.