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Implications of Resident Memory T Cells for Transplantation
Author(s) -
Beura L. K.,
Rosato P. C.,
Masopust D.
Publication year - 2017
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14101
Subject(s) - transplantation , context (archaeology) , population , immunology , immune system , biology , medicine , neuroscience , paleontology , surgery , environmental health
Recent studies have established resident memory T cells ( T RM ) as the dominant memory lymphocyte population surveying most nonlymphoid tissues. Unlike other memory T cell lineages, T RM do not recirculate through blood and are permanently confined to their tissue of residence. T RM orchestrate local immune responses and have been shown to accelerate local pathogen control in many experimental infection models. Here we briefly summarize recent advances in T RM differentiation, maintenance, and their protective function. While little is known, we have speculated on the potential implications of T RM for transplantation biology. Areas of emphasis include the role of passenger T RM in controlling latent viral recrudescence in donor organs, donor T RM as a source of graft‐versus‐host disease, the ability of T RM to potently induce inflammation through sensing and alarm functions, and differentiation of host T cells into T RM in response to local cues inside the allograft. Further investigation of T RM in the context of transplantation might identify therapeutic targets to prolong graft survival.