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B Cells Gasping for Air
Author(s) -
Alegre MariaLuisa
Publication year - 2016
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14069
Subject(s) - germinal center , immunoglobulin class switching , immune system , immunology , spleen , isotype , medicine , microbiology and biotechnology , antibody , in vivo , biology , b cell , genetics , monoclonal antibody
Cho and colleagues explore the impact of pO2 levels on germinal center B cell responses and demonstrate that sensing oxygen deprivation results in hypoxia‐induced factor‐dependent reduction of high affinity IgG class‐switched responses.