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APOL1 ‐Associated End‐Stage Renal Disease in a Living Kidney Transplant Donor
Author(s) -
Zwang N. A.,
Shetty A.,
SustentoReodica N.,
Gordon E. J.,
Leventhal J.,
Gallon L.,
Friedewald J. J.
Publication year - 2016
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14035
Subject(s) - medicine , end stage renal disease , focal segmental glomerulosclerosis , nephrectomy , disease , end stage kidney disease , kidney , renal transplant , kidney transplantation , kidney disease , stage (stratigraphy) , glomerulonephritis , biology , paleontology
Homozygosity for apolipoprotein‐L1 ( APOL 1 ) risk variants has emerged as an important predictor of renal disease in individuals of African descent over the past several years. Additionally, these risk variants may be important predictors of renal allograft failure when present in a living or deceased donor. Currently, there is no universal recommendation for screening of potential donors. We present a case of end‐stage renal disease with focal segmental glomerulosclerosis in a living donor 7 years following donor nephrectomy. Genetic assessment revealed homozygosity for the G1 high‐risk APOL 1 variant.