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Peptic Ulcer Disease in Living Liver Donors: A Longitudinal Population‐Based Study
Author(s) -
Lin S.Y.,
Lin C.L.,
Liu Y.L.,
Hsu W.H.,
Lin C.C.,
Wang I.K.,
Jeng L.B.,
Kao C.H.
Publication year - 2016
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.13822
Subject(s) - medicine , cohort , hazard ratio , incidence (geometry) , cumulative incidence , confidence interval , cohort study , population , liver disease , surgery , physics , environmental health , optics
The objective of this nationwide cohort study was to investigate the risk of peptic ulcer disease ( PUD ) in living liver donors ( LD s). A total of 1333 LD s and 5332 matched nondonors were identified during 2003–2011. Hospitalized patients identified as LD s were assigned to the LD cohort, and the non‐ LD comparison cohort comprised age‐ and sex‐matched nondonors. Cumulative incidences and hazard ratios ( HR s) were calculated. The overall incidence of PUD was 1.74‐fold higher in the LD cohort than in the non‐ LD cohort (2.14 vs. 1.48 per 1000 person‐years). After adjustment for age, sex, monthly income and comorbidities, we determined that the LD cohort exhibited a higher risk of PUD than did the non‐ LD cohort (adjusted HR 1.74, 95% confidence interval [ CI ] 1.45–2.09). The incidence of PUD increased with age; the risk of PUD was 2.53‐fold higher in patients aged ≥35 years (95% CI 2.14–2.99) than in those aged ≤34 years. LD s with comorbidities of osteopathies, chondropathies and acquired musculoskeletal deformities exhibited a higher risk of PUD (adjusted HR 3.93, 95% CI 2.64–5.86) compared with those without these comorbidities. LD s are associated with an increased risk of PUD after hepatectomy.