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Regulatory T Cells in Kidney Transplantation: New Directions?
Author(s) -
Braza F.,
Durand M.,
Degauque N.,
Brouard S.
Publication year - 2015
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.13395
Subject(s) - foxp3 , medicine , transplantation , phenotype , epigenetics , kidney , function (biology) , kidney transplantation , immunology , computational biology , cancer research , bioinformatics , biology , microbiology and biotechnology , gene , immune system , genetics
The contribution of regulatory T cells in the maintenance of kidney graft survival is of major interest. Although many experimental models suggest a role in the induction of graft tolerance, reproducing these findings in clinic is less clear. While modulation of the regulatory T cell response is a promising therapeutic concept in transplantation, a better understanding of function, phenotype and biology is needed to be able to optimally exploit these cells in order to induce graft tolerance. With this in mind, we review here the current understanding of the phenotypic‐functional delineation of Tregs and how Tregs can contribute to graft survival. We highlight their potential role in long‐term graft survival and kidney operational tolerance. We also discuss the mechanisms needed for the molecular development of regulatory T cells: A combination of FOXP3 molecular partners, epigenetic, metabolic, and posttranslational modifications are necessary to generate well‐functioning regulatory T cells and maintain their core identify. We discuss how an improved understanding of these mechanisms will permit the identification of new potent therapeutic strategies to improve kidney graft survival.