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High‐Resolution HLA Typing for Sensitized Patients: Advances in Medicine and Science Require Us to Challenge Existing Paradigms
Author(s) -
Duquesnoy R. J.,
Gebel H. M.,
Woodle E. S.,
Nickerson P.,
BaxterLowe L. A.,
Bray R. A.,
Claas F. H. J.,
Eckels D. D.,
Friedewald J. J.,
Fuggle S. V.,
Gerlach J. A.,
Fung J. J.,
Kamoun M.,
Middleton D.,
Shapiro R.,
Tambur A. R.,
Taylor C. J.,
Tinckam K.,
Zeevi A.
Publication year - 2015
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.13376
Subject(s) - human leukocyte antigen , epitope , scopus , medicine , typing , allele , antibody , antigen , immunology , computational biology , genetics , medline , biology , gene , biochemistry
In the April issue of AJT, an editorial by Cecka et al (1) commented on our personal viewpoint article wherein we proposed that HLA mismatch acceptability for sensitized transplant candidates should be determined at highresolution levels (2). This editorial seems to express the view that HLA antigen-based testing be maintained as is despite its inherent deficiencies. We are perplexed by conflicting comments that more HLA complexity ‘‘should be pretty low on the list of priorities’’ while simultaneously mentioning a need for HLA-DQA and DP typing and ‘‘better’’ resolution of HLA-DRB3/4/5 types.