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Calciphylaxis in Simultaneous Liver–Kidney Transplantation
Author(s) -
Bohorquez H. E.,
Chamorro N.,
Garces J.,
Cohen A. J.,
Reichman T. W.,
Davis N. K.,
Vincent B.,
Bruce D. A.,
Carmody I. C.,
Moiz A,
Staffeld C.,
Loss G. E.
Publication year - 2015
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.13082
Subject(s) - calciphylaxis , medicine , kidney transplantation , surgery , liver transplantation , sepsis , transplantation , kidney disease , kidney , disease
We present four patients who underwent simultaneous liver–kidney transplantation (SLK) and were diagnosed with calciphylaxis, also known as calcific uremic arteriolopathy (CUA). Common characteristics included high MELD scores (mean 35.2 ± 4.8) and advanced renal disease (duration range 6–44 weeks). CUA was diagnosed within the first 2 months post‐SLK based on clinical features. Severe morbidity and prolonged hospital stay were observed and one of the patients died secondary to sepsis. Treatment included metabolic support, wound care, calcium level correction and use of sodium thiosulphate. CUA should be considered in the presence of painful dermatologic changes in patients status post SLK.