Premium
Liver Transplantation With Aged Donors in Patients With Hepatitis C Virus
Author(s) -
Gastaca M.,
Prieto P.,
Valdivieso A.,
Ortiz de Urbina J.
Publication year - 2015
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.13068
Subject(s) - medicine , liver transplantation , hazard ratio , hepatitis c virus , transplantation , hepatitis c , surgery , retrospective cohort study , multivariate analysis , gastroenterology , virus , immunology , confidence interval
We read with great interest the study by Ghinolfi et al (1) recently published in American Journal of Transplantation. In this report, 5-year patient and graft survival rates with donors 80 years were outstanding—78.2% and 77.1%, respectively. Hepatitis C virus (HCV) status was the most significant factor of graft survival at multivariate analysis (hazard ratio 1.749, p< 0.001). At the latest follow-up, clinically significant HCV recurrence was observed in 13.6% and 9% of the patients transplanted with donors between 70 and 79 years of age and 80 years, respectively; comparable to that observed with younger donors. Of note, 5-year graft survival of the HCV-positive recipients transplanted with donors 80 years was 62.4% which, albeit significantly lower than that of the non-HCV recipients, is surprisingly high. Unfortunately, information on late graft loss and late retransplantation is not provided by the authors.