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Literature Watch Implications for transplantation
Author(s) -
Ford Mandy L.,
Bromberg Jonathan M.
Publication year - 2014
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.12949
Subject(s) - memory cell , cd8 , immunology , t cell , antigen , immune system , microbiology and biotechnology , biology , medicine , physics , transistor , quantum mechanics , voltage
Understanding the mechanisms by which memory T cells are generated and rapidly reactivated when exposed to donor antigen is critical to the design of successful tolerance induction strategies. Recent data demonstrate the significant role of cellular metabolism in controlling both memory T cell generation and reactivation.