Premium
Literature Watch Implications for transplantation
Author(s) -
Maltzman Jonathan S.,
Bromberg Jonathan S.
Publication year - 2014
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.12768
Subject(s) - pten , tensin , cancer research , suppressor , phosphatase , immunosuppression , medicine , transplantation , cancer , biology , pi3k/akt/mtor pathway , microbiology and biotechnology , immunology , signal transduction , phosphorylation
A recent publication identified a previously unappreciated form of PTEN, a tumor suppressor that is mutated in multiple cancers, with some surprising properties that suggest this protein can be transferred from one cell to another. The results offer the possibility of designing specific peptide‐based drugs to target cells for immunosuppression or tolerance induction.