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Literature Watch Implications for transplantation
Author(s) -
Li Xian C.,
Bromberg Jonathan
Publication year - 2014
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.12729
Subject(s) - foxp3 , pi3k/akt/mtor pathway , il 2 receptor , cd8 , effector , transplantation , cancer research , immunology , microbiology and biotechnology , t cell , medicine , immune system , biology , signal transduction
Considerable focus has been directed toward the identification of immunosuppressive approaches that both inhibit allospecific effectors while simultaneously stimulating and expanding Foxp3+ Tregs, and recent literature supports a paradigm in which mTOR inhibition favors Foxp3+ Tregs over T effector cells.
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