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Harnessing Regulatory T Cells for Clinical Use in Transplantation: The End of the Beginning
Author(s) -
Juvet S. C.,
Whatcott A. G.,
Bushell A. R.,
Wood K. J.
Publication year - 2014
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.12647
Subject(s) - alloimmunity , medicine , immunosuppression , transplantation , clinical trial , intensive care medicine , immunology , population , adverse effect , environmental health
Owing to the adverse effects of immunosuppression and an inability to prevent chronic rejection, there is a pressing need for alternative strategies to control alloimmunity. In three decades, regulatory T cells (Tregs) have evolved from a hypothetical mediator of adoptively transferred tolerance to a well‐defined population that can be expanded ex vivo and returned safely to patients in clinical trials. Herein, we review the historical developments that have permitted these advances and the current status of clinical trials examining Tregs as a cellular therapy in transplantation. We conclude by discussing the critical unanswered questions that face this field in the coming years.