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An Orchestrated Dance Between Differing Regulatory T Cell Phenotypes in Allograft Tolerance
Author(s) -
Gill R. G.
Publication year - 2013
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.12336
Subject(s) - foxp3 , regulatory t cell , immunology , transplantation , il 2 receptor , peripheral tolerance , regulatory b cells , immune tolerance , medicine , immune system , biology , microbiology and biotechnology , t cell , interleukin 10
While the field has focused largely on Foxp3+ Tregs as mediators of regulatory allograft tolerance, a new study provides evidence that a ‘division of labor’ can occur between Tregs and IL‐10‐producing Tr1 cells in which each regulatory cell type can be required during differing phases of the tolerogenic response. See article by Gagliani et al on page 1963.