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Challenges to Research and Innovation to Optimize Deceased Donor Organ Quality and Quantity
Author(s) -
Abt P. L.,
Marsh C. L.,
Dunn T. B.,
Hewitt W. R.,
Rodrigue J. R.,
Ham J. M.,
Feng S.
Publication year - 2013
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.12243
Subject(s) - medicine , quality (philosophy) , transplantation , ambiguity , clinical trial , intensive care medicine , ethical issues , organ transplantation , intervention (counseling) , engineering ethics , operations management , risk analysis (engineering) , nursing , surgery , pathology , computer science , philosophy , epistemology , engineering , economics , programming language
Solid organ transplantation is encumbered by an increasing number of waitlisted patients unrequited by the current organ supply. Preclinical models suggest that advances in deceased donor management and treatment can increase the quantity and quality of organs available for transplantation. However, the science of donor intervention and the execution of high quality, prospective, multi‐center, randomized‐controlled trials are restricted by a myriad of logistical challenges mired in regulatory and ethical ambiguity. By highlighting the obstacles to conducting research in deceased donors, this report endeavors to stimulate the creation of a multi‐disciplinary framework to facilitate the design, implementation and supervision of innovative trials that increase the quantity and/or quality of deceased donor organs.