Premium
Mycobacterium tuberculosis Infections in Solid Organ Transplantation
Author(s) -
Subramanian A. K.,
Morris M. I.
Publication year - 2013
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.12100
Subject(s) - medicine , tuberculosis , solid organ , transplantation , microbiology and biotechnology , mycobacterium tuberculosis , organ transplantation , pathology , biology
The diagnosis and treatment of tuberculosis (TB) in organ transplant recipients presents several challenges. Impediments to rapid and accurate diagnosis may lead to treatment delay and include negative or indeterminate tuberculin skin tests (TST) or interferon-gamma release assays (IGRA), negative sputum smear results despite active disease and atypical clinical presentations (1–3). Therapeutic challenges arise from drug related toxicities, metabolic interactions between immunosuppressive and antituberculous drugs and side effects from antituberculous medications (4). Increasing drug resistance and inadequate immune responses to Mycobacterium tuberculosis (MTB) due to exogenous immunosuppression increase the complexity of treating TB in this population (5).