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TNFα, TGFβ, Pseudomonas and Classically Activated Macrophages Conspire to Reprogram the Airways in Obliterative Bronchiolitis
Author(s) -
Neujahr D. C.
Publication year - 2013
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.12069
Subject(s) - mesenchymal stem cell , medicine , pathology , lung , lung transplantation , transplantation , fibrosis , cystic fibrosis , immunology , bronchiolitis , reprogramming , wound healing , epithelial–mesenchymal transition , cancer research , biology , cell , virus , genetics , cancer , metastasis
A perfect storm of inflammatory signals and bacteria conspire to drive alveolar macrophages toward a phenotype capable of inducing small airway fibrosis in lung transplant recipients. See article by Borthwick et al on page 621.