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Vitamin B3 levels in women who experience first‐trimester miscarriage
Author(s) -
Yakob Nurul A.,
Peek Michael J.,
Quinlivan Julie A.
Publication year - 2021
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.13341
Subject(s) - miscarriage , niacin , medicine , pregnancy , obstetrics , first trimester , prospective cohort study , gynecology , gestation , endocrinology , biology , genetics
Miscarriage is the most common complication in early pregnancy. It was recently reported in mice that miscarriage can be prevented through the administration of niacin. We conducted a prospective, exploratory pilot study involving 24 women who were less than 14 weeks pregnant. Neither niacin intake ( P = 0.24) nor urinary vitamin B3 measured as the 1‐methyl‐5‐carboxylamide‐2‐pyridone/ N ‐1‐methylnicotinamide (2‐pyr/MNA) ratio ( P = 1.00) predicted miscarriage. However, the difference in mean 2‐pyr/MNA ratios between women who miscarried and controls suggests there may be a threshold niacin level protective in miscarriage prevention warranting further investigation.