Premium
Interval between IVF stimulation cycle and frozen embryo transfer: Is there a benefit to a delay between cycles?
Author(s) -
Higgins Chloe,
Healey Martin,
Jatkar Sameer,
Vollenhoven Beverley
Publication year - 2018
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12696
Subject(s) - embryo transfer , live birth , odds ratio , pregnancy , in vitro fertilisation , medicine , confidence interval , embryo , retrospective cohort study , obstetrics , odds , gynecology , biology , logistic regression , genetics , microbiology and biotechnology
Background There is currently limited evidence available regarding ideal timing for frozen embryo transfer (FET). Demonstrating that delaying FETs has few clinical benefits would allow patients to proceed with FET at their earliest convenience. Aims To examine whether the time interval between stimulation cycle and subsequent FET affects pregnancy and live birth rates. Materials and methods This retrospective cohort study, based in a multi‐site private in vitro fertilisation (IVF) clinic categorised women into two groups: those having FET cycles administered within 25–35 days or 50–70 days of IVF stimulation cycle and embryo freeze. Outcomes measured were clinical pregnancy and live birth rates. Results When comparing the patients who have had a 25–35 days gap between embryo freeze and FET, to the matched patients who had a 50–70 days gap, the statistically significant results showed an adjusted odds ratio for live birth of 1.31 (1.02–1.67). The adjusted odds ratio for clinical pregnancy in matched case : control analysis was not statistically significant at 1.22 (0.97–1.53). Conclusion A gap of 25–35 days between embryo freeze and FET was associated with improved live birth rates compared to a gap of 50–70 days.