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The role of staging surgery in the treatment of apparent early‐stage malignant ovarian germ cell tumours
Author(s) -
Zhao Ting,
Zhang Hao,
Liu Yan,
Jiang Hongyuan,
Wang Xiao,
Lu Yuan
Publication year - 2016
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12468
Subject(s) - medicine , stage (stratigraphy) , univariate analysis , surgery , survival analysis , chemotherapy , exact test , germ cell tumors , multivariate analysis , paleontology , biology
Background Malignant ovarian germ cell tumours ( MOGCT s) are usually detected at an early stage, with patients achieving a satisfactory prognosis. However, the role of staging surgery in the treatment of apparent early‐stage MOGCT s remains controversial. Aims To investigate the role of staging procedures in apparent early‐stage patients. Materials and Methods We performed a retrospective review of 102 patients who were diagnosed with MOGCT s and had malignant lesions confined to their ovaries, between January 1997 and October 2014 at the Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. Statistical analysis was carried out using SPSS software which included survival analysis by Kaplan–Meier method and Fisher's exact test. Results Three patients relapsed and one died. The five‐year overall survival rate and disease‐free survival rate were 98.7% and 96.4%, respectively. Eighty‐nine patients (87.3%) received adjuvant chemotherapy and only 23 patients (22.5%) were completely staged. In total, 3/49 (6.1%), 1/44 (2.3%) and 0/49 (0.0%) patients were diagnosed with malignant cells in peritoneal fluid, pelvic lymph nodes and omentum, respectively. Positive tumour cells were not correlated with recurrence. Univariate analysis revealed that neither complete staging surgery nor individual factors were useful prognostic factors for disease‐free survival. Conclusions The staging surgery could be omitted for apparent early‐stage patients affected by MOGCT s without adverse impact upon survival.