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Venous thromboembolism prophylaxis during and following caesarean section: a survey of clinical practice
Author(s) -
Seeho Sean K.M.,
Nippita Tanya A.,
Roberts Christine L.,
Morris Jonathan M.,
Nassar Natasha
Publication year - 2016
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12393
Subject(s) - caesarean section , venous thromboembolism , medicine , section (typography) , clinical practice , intensive care medicine , pregnancy , surgery , physical therapy , thrombosis , computer science , genetics , biology , operating system
Background Caesarean section ( CS ) is a significant risk factor for venous thromboembolism; however, the optimal method of thromboprophylaxis around the time of CS is unknown. Aims To examine current thromboprophylaxis practice during and following CS in Australia and New Zealand, and the willingness of obstetricians to participate in a randomised controlled trial ( RCT ) comparing different methods of thromboprophylaxis after CS . Materials and Methods An online survey was sent to fellows and trainees of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists. Results There were 488 responses from currently practising obstetricians (response rate 23.4%). During CS , 48% and 80% of obstetricians recommended intermittent pneumatic compression ( IPC ) and elastic stockings ( ES ), respectively. Following CS , 96–97% of obstetricians recommended early ambulation, 87–90% recommended ES , 23–36% recommended IPC , and 42–65% recommended low molecular weight heparin ( LMWH ) depending on clinical factors. Increased BMI ( OR 3.42; 95% CI 2.87–4.06), emergency CS ( OR 1.88; 95% CI 1.67–2.16) and older maternal age ( OR 1.37; 95% CI 1.26–1.49) were associated with more frequent LMWH use. Of obstetricians who prescribed LMWH , 70% adjusted the dose depending on maternal weight. LMWH therapy was most commonly recommended until discharge from hospital (31%), <5 days (24%) and 5–7 days (15%). Most obstetricians (58–79%) were willing to enrol women in a RCT , but less likely if the woman had an increased BMI or emergency CS . Conclusions There is considerable variation in clinical practice regarding thromboprophylaxis during and following CS . Obstetricians support a RCT to assess different methods of thromboprophylaxis following CS .