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National decline in invasive prenatal diagnostic procedures in association with uptake of combined first trimester and cell‐free DNA aneuploidy screening
Author(s) -
Robson Stephen J.,
Hui Lisa
Publication year - 2015
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12380
Subject(s) - amniocentesis , chorionic villus sampling , medicine , cell free fetal dna , obstetrics , aneuploidy , prenatal diagnosis , trisomy , pregnancy , gynecology , fetus , genetics , biology , chromosome , gene
In late 2012, a new screening test for fetal aneuploidy based on circulating cell‐free DNA (cf DNA ) became available to Australian women. The introduction of this technology in the United States has led to a reduction in invasive diagnostic procedures. Analysis of the number of amniocentesis and chorionic villus sampling ( CVS ) procedures performed in Australia from 1994 to 2014 shows that the introduction of cf DNA testing has been associated with the most rapid decline in invasive procedures in the last 20 years. This change has important implications for training in, and maintenance of, the procedural skills of amniocentesis and CVS .