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Rectal misoprostol for myomectomy: A randomised placebo‐controlled study
Author(s) -
AbdelHafeez Mohamed,
Elnaggar Ahmed,
Ali Mohamed,
Ismail Abdel Mgeed,
Yacoub Mina
Publication year - 2015
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12359
Subject(s) - medicine , misoprostol , placebo , blood loss , randomized controlled trial , uterine myomectomy , surgery , leiomyoma , myoma , clinical trial , obstetrics , uterus , pregnancy , abortion , genetics , alternative medicine , pathology , biology
Background Uterine leiomyomas are the most common benign tumours in women . Misoprostol, which is widely used in the treatment and prevention of postpartum haemorrhage in obstetrics, may decrease intra‐operative bleeding in abdominal myomectomies when haemorrhage constitutes a challenging problem. Aims To assess the effect on intra‐operative blood loss of using a single pre‐operative dose of rectal misoprostol in abdominal myomectomy surgeries. Materials and Methods In a randomised double‐blind placebo‐controlled trial, 50 women undergoing abdominal myomectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of pre‐operative of rectal 400 μg misoprostol ( n  = 25) or placebo ( n  = 25) 1 h before the operation. The primary outcome was intra‐operative blood loss. This clinical trial was registered in clinicaltrial.gov registry with number: NCT 02061657. Results Intra‐operative blood loss was significantly lower in those women randomised to receive rectal misoprostol versus the placebo group (574 ± 194.8 mL vs 874 ± 171.5 mL). Additionally, the drop in postoperative haemoglobin was significantly less in the misoprostol group (1.7 ± 0.4 g/dL) compared with the placebo group (2.1 ± 0.5 g/dL). Conclusion A single pre‐operative dose of rectal misoprostol (400 μg) is a simple applicable method for reducing intra‐operative blood loss and operative time in abdominal myomectomy.

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