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Gn RH agonist trigger and a freeze‐all strategy to prevent ovarian hyperstimulation syndrome: A retrospective study of OHSS risk and pregnancy rates
Author(s) -
Atkinson Paul,
Koch Juliette,
Ledger William L.
Publication year - 2014
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12277
Subject(s) - ovarian hyperstimulation syndrome , agonist , pregnancy , pregnancy rate , controlled ovarian hyperstimulation , embryo transfer , gynecology , medicine , embryo cryopreservation , andrology , gonadotropin releasing hormone agonist , live birth , oocyte , in vitro fertilisation , obstetrics , embryo , biology , receptor , buserelin , genetics , microbiology and biotechnology
Aims To analyse the data from all controlled ovarian hyperstimulation antagonist cycles that used an agonist trigger and a freeze‐all strategy to quantify the risk of ovarian hyperstimulation syndrome ( OHSS ) and subsequent pregnancy rates. Materials and Methods A retrospective study of all women attending fertility clinics at IVF Australia, Sydney, undergoing controlled ovarian hyperstimulation (COH) using an antagonist protocol that had a subsequent gonadotropin‐releasing hormone (GnRH) agonist trigger and freezing of all oocytes or embryos. The primary outcome measure was to determine the rate of OHSS. The secondary outcome measure was the clinical pregnancy rate. Results We collected data for 123 women. 25.2% were undergoing oocyte freezing and 74.8% underwent embryo freezing. There were no cases of OHSS , either early or late onset. The pregnancy rate was 31.7% after the first frozen cycle transfer with a cumulative pregnancy rate of 50% after two frozen embryo transfers. Conclusion Our results support the hypothesis that a Gn RH agonist trigger and a freeze‐all approach prevents OHSS with a good pregnancy rate.