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Maternal body weight and first trimester screening for chromosomal anomalies
Author(s) -
Khambalia Amina Z.,
Roberts Christine L.,
Morris Jonathan,
Tasevski Vitomir,
Nassar Natasha
Publication year - 2014
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12231
Subject(s) - biomarker , obstetrics , medicine , pregnancy , down syndrome , population , birth weight , first trimester , body weight , gestation , biology , environmental health , genetics , psychiatry
Prenatal risk ratios for D own syndrome adjust for maternal weight because maternal serum biomarker levels decrease with increasing maternal weight. This is accomplished by converting serum biomarker values into a multiple of the expected median ( MoM ) for women of the same gestational age. Weight is frequently not recorded, and the impact of using MoM s not adjusted for weight for calculating risk ratios is unknown. The aim of this study is to examine the effect of missing weight on first trimester D own syndrome risk ratios by comparing risk ratios calculated using weight‐unadjusted‐and‐adjusted MoM s. Findings at the population level indicate that the impact of not adjusting for maternal weight on first trimester screening results for chromosomal anomalies would lead to under‐identification of 84 per 10 000 pregnancies.