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Ovarian fibroma/fibrothecoma: Retrospective cohort study shows limited value of risk of malignancy index score
Author(s) -
Numanoglu Ceyhun,
Kuru Oguzhan,
Sakinci Mehmet,
Akbayır Ozgur,
Ulker Volkan
Publication year - 2013
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12090
Subject(s) - fibroma , medicine , pathological , malignancy , ovary , predictive value , retrospective cohort study , radiology , gynecology , pathology
Background Ovarian fibromas/fibrothecomas are uncommon benign tumours of ovary. Due to their solid structure, these benign tumours are sometimes confused with malignant tumours during clinical evaluation. Aims To determine the clinico‐pathological characteristics of ovarian fibroma/fibrothecoma and analyse the efficiency of risk of malignancy index ( RMI ) scoring system to distinguish malignancy among these tumours. Methods Between N ovember 2001 and F ebruary 2012, women with a pathological diagnosis of ovarian fibroma/fibrothecoma were identified. Depending on the menopausal status, serum CA ‐125 level and ultrasonographic findings, RMI scores were calculated for each of the patients. Results During the study period, 43 ovarian fibroma/fibrothecoma (4.7%) were detected among 912 adnexal masses operated. The mean age of the women was 52.2 (range, 21–80 years). Upon calculating RMI scores, 33 women (76.7%) were classified as low risk and 10 women (23.3%) as high risk for malignancy. Sensitivity, specificity, positive predictive value and negative predictive value of the RMI scoring for identification of malignant lesions preoperatively were found as 0%, 76%, 0% and 97%, respectively. Final pathological diagnosis was ovarian fibroma in 13 (30%) women, fibrothecoma in 29 (67%) and fibrosarcoma in one woman (2%). Conclusion There are no specific markers for accurate preoperative diagnosis of ovarian fibroma/fibrothecoma. Moreover, according to our results, RMI scoring system does not aid clinicians in this issue either, with a high false‐positive rate and very low sensitivity. Further studies with higher number of cases are needed to state clearly the role of RMI scores in preoperative discrimination of malignancy.