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A nested case–control study to evaluate the association between fetal growth restriction and vitamin B12 deficiency
Author(s) -
Abraham Anuja,
Mathews Jiji E.,
Sebastian Ajit,
Chacko Kuruvilla P.,
Sam Dibu
Publication year - 2013
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/ajo.12057
Subject(s) - nested case control study , medicine , vitamin b12 , socioeconomic status , statistical significance , fetus , cohort , gestation , cohort study , obstetrics , pregnancy , case control study , physiology , pediatrics , environmental health , population , biology , genetics
Objectives To study the association between maternal vitamin B12 levels and fetal growth restriction. Methods In this nested case–control study, a cohort of low‐risk women attending the antenatal clinic had their blood samples taken and stored at 28–31 weeks gestation. They were followed until delivery. Fifty‐eight women delivering babies less than 2500 g were taken as cases and an equal number of controls delivering babies more than 2500 g were taken from the same cohort. Their B12 levels were assayed and studied for statistical significance. Results The baseline characteristics of both groups were similar. The number of women with serum B12 levels less than 200 pg/mL were similar in both groups: 33% versus 29% ( P = 0.84). Type of kitchen fuel used was taken as a surrogate marker for socioeconomic status. More women in the cases used non‐ LPG (liquid petroleum gas) kitchen fuels such as kerosene and wood than in controls, 35% versus 19% ( P = 0.06). Conclusions No association between maternal vitamin B12 levels and fetal growth restriction was found in this study. Low birth weight babies were more common in women of low socioeconomic status.