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P37: Innate lymphoid cells at the maternal‐fetal interface in human pregnancy
Author(s) -
Rui-Qi Chang,
Wen-Jie Zhou,
Da-Jin Li,
Ming-Qing Li
Publication year - 2019
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.36_13120
Subject(s) - pregnancy , citation , interface (matter) , fetus , innate lymphoid cell , medicine , immunology , biology , computer science , world wide web , innate immune system , genetics , immune system , pulmonary surfactant , biochemistry , gibbs isotherm
Pregnancy constitutes a major challenge to the maternal immune system, which must tolerate fetal alloantigen encoded by paternal genes. In addition to their role in inducing maternal-fetal immune tolerance, accumulating evidence indicates that decidual immune cells are involved in several processes required for a successful pregnancy, including trophoblast invasion as well as tissue and spiral artery remodeling. Innate lymphoid cells (ILCs), an important branch of the innate immune system, which has expanded rapidly in recent years, are strong actors in mucosal immunity, tissue homeostasis and metabolism regulation. With the recent identification of ILCs in the human decidua, the role of ILCs at the maternal-fetal interface raises concern. Herein, we review the presence and characterization of ILCs in the human decidua, as well as their function in normal pregnancy and pathological pregnancy, including reproductive failure, preeclampsia and others.