Premium
Angiogenic cytokine and interleukin 8 levels in early luteal phase after triggering ovulation with gonadotropin‐releasing hormone agonist in high‐responder patients
Author(s) -
Martazanova Bella,
Mishieva a,
Vtorushina Valentina,
Vedikhina Irina,
Levkov Lev,
Korneeva Irina,
Kirillova Anastasia,
Krechetova Lubov,
Abubakirov Aydar,
Sukhikh Gennady T.
Publication year - 2021
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.13381
Subject(s) - human chorionic gonadotropin , medicine , ovarian hyperstimulation syndrome , endocrinology , luteal phase , agonist , ovulation , vascular endothelial growth factor , ovulation induction , gonadotropin , gonadotropin releasing hormone , cytokine , follicular phase , oocyte , gonadotropin releasing hormone agonist , hormone , biology , receptor , andrology , pregnancy , embryo , in vitro fertilisation , luteinizing hormone , vegf receptors , genetics , microbiology and biotechnology
Abstract Problem Interleukin 8 (IL‐8), vascular endothelial growth factor A (VEGFA), its receptors 1 (VEGFR1) and 2 (VEGFR2) are associated with ovarian hyperstimulation syndrome (OHSS) pathophysiological mechanisms. The aim of this study was to evaluate the concentrations of these cytokines depending on the way of ovulation triggering. Method of Study A total of 51 high‐responder patients underwent IVF program and received gonadotropin‐releasing hormone agonists (GnRHa) trigger + 1500 IU human chorionic gonadotropin (hCG) support on the oocyte pick‐up (OPU) day (group I), dual trigger (GnRHa + 1500 IU hCG; group II), or hCG trigger 10,000 IU (group III) for the final oocyte maturation. The concentrations of cytokines were evaluated in serum by the enzyme‐linked immunosorbent assay kit. Result(s) VEGFR2 levels were significantly lower in groups I and II than in group III in serum on the OPU (I vs. III, p = .0456; II vs. III, p = .0122) and OPU + 5 day (I vs. III, p = .0004; II vs. III, p = .0082). VEGFA levels were lower in group I than in group III ( p = .0298) on the OPU day, however, were similar in all groups on the OPU + 5 day. Conclusion(s) A small dose of hCG elicits similar concentrations of VEGFA to a full dose of hCG; however, GnRHa triggering reduces the concentrations of VEGFR2, which could lead to the OHSS prevention.