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Evaluation of carcinoembryonic antigen‐related cell adhesion molecule 1 blood serum levels in women at high risk for preeclampsia
Author(s) -
Mach Pawel,
Andrikos Dimitrios,
Schmidt Boerge,
Gellhaus Alexandra,
Rusch Peter,
Birdir Cahit,
Andrikos Argyrios,
Schmitt Verena,
Kimmig Rainer,
Singer Bernhard B.,
Köninger Angela
Publication year - 2021
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.13375
Subject(s) - medicine , carcinoembryonic antigen , pregnancy , preeclampsia , third trimester , obstetrics , cell adhesion molecule , adhesion , first trimester , gastroenterology , immunology , gestation , biology , chemistry , genetics , organic chemistry , cancer
Abstract Problem The aim of this study was to evaluate the sCEACAM1 concentrations in serum from patients in the first trimester who have a high risk for developing PE during pregnancy. Method of the study Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) levels were determined with ELISA. The patients ( n = 109) were divided into two groups: patients who have a high risk of developing PE early‐onset and a control group. Patients who have a high risk of developing PE were then divided into two subgroups depending on PE development in third trimester of pregnancy: PE in third trimester versus no PE in third trimester. Results sCEACAM1 concentrations in patients who were screened as having a high risk for developing PE were significantly higher than in healthy pregnant women in the first trimester ( p = .03). The highest sCEACAM1 concentration was found in the high‐risk group with PE development compared to the control group ( p = .004). Conclusion Elevated sCEACAM1 blood serum levels in women with PE suggest that there is immune dysregulation in early pregnancy, which may be helpful in PE prediction and therapy.