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Milk exosomes: A biogenic nanocarrier for small molecules and macromolecules to combat cancer
Author(s) -
Kandimalla Raghuram,
Aqil Farrukh,
Tyagi Neha,
Gupta Ramesh
Publication year - 2021
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.13349
Subject(s) - microvesicles , nanocarriers , cancer , macromolecule , chemistry , nanotechnology , medicine , microrna , nanoparticle , materials science , biochemistry , gene
Abstract Exosomes are unique biogenic nanocarriers of endocytic origin that are generated from most of the cells and found in biofluids like milk, plasma, saliva, and urine. Bovine milk represents the largest and an economic source for the production of exosomes. In recent past, the utility of the milk exosomes as drug carriers is intensified. Exosomes are emerging for delivery of both small and large therapeutics due to their biocompatibility. In this article, we highlighted the various exosomal isolation techniques, physicochemical properties, their biodistribution, and utility of milk exosomes in delivering the small drug molecules and siRNA to combat cancer.