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Maternal history of recurrent pregnancy loss and future risk of ophthalmic morbidity in the offspring
Author(s) -
Aharon Eran,
Wainstock Tamar,
Sheiner Eyal,
Tsumi Erez,
Pariente Gali
Publication year - 2021
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.13326
Subject(s) - medicine , offspring , pregnancy , proportional hazards model , confounding , pediatrics , family history , incidence (geometry) , obstetrics , gestational age , cohort , cumulative incidence , cohort study , survival analysis , genetics , biology , physics , optics
Objective The objective of the study was to investigate whether maternal history of recurrent pregnancy loss (RPL) is associated with offspring childhood ophthalmic morbidity. Method A hospital‐based cohort analysis comparing long‐term offspring ophthalmic morbidity in women with and without a history of RPL was performed. Ophthalmic morbidity included hospitalizations involving a pre‐defined set of ICD‐9 codes. Offspring with congenital anomalies, perinatal mortality cases, and multifetal pregnancies were excluded from the analysis. Cumulative morbidity incidence was compared using Kaplan‐Meier survival curves, and the risk of long‐term ophthalmic morbidity was assessed by Cox proportional hazards model after adjustment for confounders. Results During the study period, 242,187 newborns met the inclusion criteria; 5% (12,182) of them were offspring born to mothers with a history of RPL. Ophthalmic morbidity was significantly more common in the RPL group (1.3% vs 0.9%, p < .001, Kaplan‐Meier log‐rank p < .001). Adjustment for confounders, such as maternal age, gestational age, hypertensive disorders, and maternal diabetes, using Cox regression found that being born to a mother with RPL was independently associated with long‐term ophthalmic morbidity (adjusted HR 1.35, 95% CI 1.15‐1.59, p < .001). Conclusion Being born to a mother with RPL is independently associated with an increased risk of ophthalmic morbidity.