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Association of TNF‐α gene T‐1031C polymorphism with endometriosis: A meta‐analysis
Author(s) -
Cao XianLing,
Chai Jie,
Yu YangYang,
Tian Xiao,
Zhao JianYun,
Yu LingYu,
Sun ZhenGao
Publication year - 2020
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.13305
Subject(s) - meta analysis , odds ratio , medicine , confidence interval , allele , single nucleotide polymorphism , gastroenterology , gene polymorphism , gene , oncology , biology , genotype , genetics
The single nucleotide polymorphism T‐1031C has shown to have an important role in the regulation and transcription efficiency of TNF‐α gene. Yet, the relationship between TNF‐α T‐1031C gene polymorphism and the development of endometriosis (EM) still remains unclear. The aim of this meta‐analysis was to summarize the effects of TNF‐α T‐1031C gene polymorphism and clarify their possible association with EM. A comprehensive literature search was performed using PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials (up to August 10, 2019). A fixed‐ or random‐effects model was employed according to the heterogeneity among studies. The log odds ratios and 95% confidence intervals (CIs) were estimated in the models of allele comparison (T vs C), homozygote comparison (TT vs CC) and (TC vs CC), dominant (TT vs TC + CC), hyperdominant (TT + CC vs TC), and recessive (TT + TC vs CC) to estimate the strength of the associations. A total of 7 case‐control studies were included in this meta‐analysis. Overall, significant associations between TNF‐α T‐1031C and EM were identified from (T vs C: log OR [95% CI] = 0.31 [−0.09, 0.71]; TT + CC vs TC: 0.27 [0.04, 0.50]; TC + CC vs TT: −0.83 [−1.19, −0.47]). On the other hand, no significant correlation was found in other gene models (TT vs TC: log OR [95% CI] = 0.89 [0.64, 1.13]; TT vs CC: 0.3 [−0.74, 1.36]; TT + TC vs CC: 0.17 [−0.81, 1.15]). In subgroup analyses by ethnicity or HWE P ‐value, there was a statistically significant association between TNF‐α T‐1031C polymorphisms and EM in the dominant model (TT vs TC + CC: log OR [95%] = −0.84 [−1.60, −0.09]) for the European population, and in hyperdominant model (TT + CC vs TC: log OR [95%] = 0.24 [0.001, 0.49]) for Asian population. To sum up, this meta‐analysis showed that TNF‐α T‐1031C polymorphism was associated with EM susceptibility and has a protective effect in Asian and European populations.