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CD25 + FOXP3 + and CD4 + CD25 + cells distribution in decidual departments of women with severe and mild pre‐eclampsia: Comparison with healthy pregnancies
Author(s) -
Orlovic Vlaho Martina,
Tomic Vajdana,
Vukojevic Katarina,
Vasilj Anja,
Pejic Renato,
Lesko Josip,
Soljic Violeta
Publication year - 2020
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.13281
Subject(s) - decidua , il 2 receptor , foxp3 , medicine , andrology , endocrinology , immunohistochemistry , pregnancy , biology , placenta , immunology , t cell , immune system , fetus , genetics
Problem The aim of this study was to quantify and compare the distribution of regulatory CD25 + FOXP3 + and activated CD4 + CD25 + T cells in decidua basalis and parietalis of severe and mild pre‐eclampsia (PE) to normal healthy pregnancies. Method of study Decidual tissue (decidua basalis and parietalis) of 13 women with mild PE, 15 women with severe PE, and 19 women with healthy term pregnancies were analyzed by immunohistochemistry and double immunofluorescence. Results The total number of CD25 + FOXP3 + cells/mm 2 in decidua basalis was decreased in the severe and mild PE versus normal pregnancy group. The total number of CD4 + CD25 + cells/mm 2 in decidua basalis was decreased in the severe PE versus normal pregnancy group. The number of CD25 + FOXP3 + and CD4 + CD25 + cells in decidua parietalis was decreased in both PE groups. Conclusion Our data suggest that immunological changes of PE reflect on decidua basalis and parietalis and emphasize the importance of characterizing T cells in both decidual departments.