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Tacrolimus treatment for infertility related to maternal‐fetal immune interactions
Author(s) -
Yamaguchi Koushi
Publication year - 2019
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.13097
Subject(s) - infertility , tacrolimus , immunity , medicine , fetus , transplantation , unexplained infertility , immune system , pregnancy , immunology , biology , genetics
Many approaches have been used to achieve successful pregnancies in patients with infertility, though existing treatments remain unsatisfactory in patients with infertility caused by abnormal maternal‐fetal immunity. However, our understanding of the immunological aspects of infertility has steadily progressed, aided by recent research into organ transplantation and cancer. The results of these recent analyses have led to the development and evaluation of several candidate immunological treatments, but the use of immunological treatments remains a novel approach. The current paper presents the hypothesis that tacrolimus may have potential as a candidate agent for the treatment of maternal‐fetal immunity‐related infertility.