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Toll‐like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease
Author(s) -
Taylor Brandie D.,
Totten Patricia A.,
Astete Sabina G.,
Ferris Michael J.,
Martin David H.,
Ness Roberta B.,
Haggerty Catherine L.
Publication year - 2018
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12804
Subject(s) - pelvic inflammatory disease , biology , chlamydia , gonorrhea , infertility , gynecology , bacterial vaginosis , cervicitis , population , tubal factor infertility , chlamydia trachomatis , immunology , medicine , genetics , pregnancy , environmental health , human immunodeficiency virus (hiv)
Problem Toll‐like ( TLR ) receptor genetic variants have been implicated in bacterial vaginosis ( BV ). We determined whether TLR variants are associated with fastidious BV ‐associated microbes that are linked with infertility following pelvic inflammatory disease ( PID ). Method of study Sneathia spp., Atopobium vaginae , BVAB 1, and Ureaplasma urealyticum were measured in 250 women from the PID Evaluation and Clinical Health ( PEACH ) study. Relative risk ( RR ) and 95% confidence intervals ( CI ) were calculated adjusting for chlamydia and gonorrhea. Principal component analysis was used to adjust for population stratification. A false discovery rate q‐value of 0.05 was significant. Results TLR 2‐1733C>A ( P = .003) and TLR 2‐616A>G ( P = .004) were associated with cervical A. vaginae . TLR 2‐1733C>A and TLR 6‐438C>T were associated with A. vaginae detection in the endometrium, but this was not significant after adjustment for multiple comparisons ( FDR q‐value = 0.06). Conclusion Host gene variants in TLR 2 signaling pathways were modestly associated with cervical A. vaginae in women with clinical PID .