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Gestational tissue inflammatory biomarkers at term labor: A systematic review of literature
Author(s) -
Hadley Emily E.,
Richardson Lauren S.,
Torloni Maria R.,
Me Ramkumar
Publication year - 2018
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12776
Subject(s) - myometrium , decidua , amnion , placenta , preterm labor , inflammation , biology , gestation , medicine , fetus , bioinformatics , pregnancy , immunology , uterus , endocrinology , genetics
Parturition at term is characterized by inflammatory overload in both feto‐maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand their mechanistic contributions to labor. This systematic review investigated the pro‐ and anti‐inflammatory biomarkers reported in intra‐uterine tissues (amnion, chorion, decidua, placenta, and myometrium) at term labor. We conducted a systematic review of studies on pro‐ and anti‐inflammatory biomarkers (mRNA and/or protein) reported in feto‐maternal tissues during normal human term labor, published in English (1980‐2016), in 3 electronic data bases. From a total of 3712 citations, 172 were included for final review. Each tissue expresses a unique set of biomarkers at the time of term labor, but there is significant overlap between tissues. All tissues had IL ‐6, IL ‐8, IL ‐1β, COX ‐2, PGE ‐2, TNF ‐α, and hCAP 18 in common at term labor. Common and unique inflammatory biomarkers are expressed in various feto‐maternal compartments at term labor. Increase in pro‐inflammatory markers in all gestational tissue signifies their harmonious functional role in promoting labor. Anti‐inflammatory markers at term labor are hardly reported.