Vitamin D deficiency in an Italian cohort of infertile women

Problem The purpose of this study was to explore whether vitamin D might be a marker of female primary infertility in association with the presence of autoimmune diseases ( AD s). Methods The study was a cross‐sectional descriptive study in consecutive outpatients of the Polymedical Center for Prevention of Recurrent Spontaneous Abortion ( RSA ), in Rome, Italy. Women were eligible if they received a diagnosis of primary infertility or RSA . Serum vitamin D, calcium, and PTH were analyzed. Results Women with primary infertility (n=70) or RSA /non‐infertile (n=105) were enrolled; controls (n=250) were included. Infertile women presented lower vitamin D ( P =0.03) and higher prevalence of AD ( P =0.007) than non‐infertile women. In the multivariate analysis, the presence of AD s is associated with higher odds of infertility (OR=2.2), while normal vitamin D was a protective factor (OR=0.9). Conclusion We described that having vitamin D deficiency and suffering from an AD are independent risk factors for women primary infertility. Supplementation of vitamin D might be useful for pregnancy outcome.