Premium
Vitamin D deficiency in an Italian cohort of infertile women
Author(s) -
Triggianese Paola,
Watad Abdulla,
Cedola Francesca,
Perricone Carlo,
Amital Howard,
Giambini Ilio,
Perricone Roberto,
Shoenfeld Yehuda,
De Carolis Caterina
Publication year - 2017
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12733
Subject(s) - medicine , infertility , pregnancy , vitamin d and neurology , obstetrics , vitamin d deficiency , gynecology , odds ratio , abortion , cohort , fertility , population , genetics , environmental health , biology
Problem The purpose of this study was to explore whether vitamin D might be a marker of female primary infertility in association with the presence of autoimmune diseases ( AD s). Methods The study was a cross‐sectional descriptive study in consecutive outpatients of the Polymedical Center for Prevention of Recurrent Spontaneous Abortion ( RSA ), in Rome, Italy. Women were eligible if they received a diagnosis of primary infertility or RSA . Serum vitamin D, calcium, and PTH were analyzed. Results Women with primary infertility (n=70) or RSA /non‐infertile (n=105) were enrolled; controls (n=250) were included. Infertile women presented lower vitamin D ( P =0.03) and higher prevalence of AD ( P =0.007) than non‐infertile women. In the multivariate analysis, the presence of AD s is associated with higher odds of infertility (OR=2.2), while normal vitamin D was a protective factor (OR=0.9). Conclusion We described that having vitamin D deficiency and suffering from an AD are independent risk factors for women primary infertility. Supplementation of vitamin D might be useful for pregnancy outcome.