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Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure
Author(s) -
Kitaya Kotaro,
Matsubayashi Hidehiko,
Takaya Yukiko,
Nishiyama Rie,
Yamaguchi Kohei,
Takeuchi Takumi,
Ishikawa Tomomoto
Publication year - 2017
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12719
Subject(s) - medicine , endometritis , metronidazole , endometrial biopsy , gynecology , infertility , live birth , antibiotics , ciprofloxacin , doxycycline , prospective cohort study , biopsy , pregnancy , biology , genetics , microbiology and biotechnology
Problem The aim of this prospective study was to investigate the prevalence of chronic endometritis (CE) in infertile women with a history of repeated implantation failure (RIF) and to determine whether oral antibiotic treatment improves their live birth rate in the following embryo transfer (ET) cycles. Method of study Endometrial biopsy samples obtained from infertile women with RIF were subjected to immunohistochemistrical/histopathologic diagnosis of CE. Following antibiotic administration to the RIF/CE group, their histopathologic cure rate, microbial detection rate, and reproductive outcome in the subsequent ET cycles were prospectively studied. Results 33.7% of infertile women with RIF were diagnosed with CE. Following the first‐line doxycycline treatment, the histopathologic cure rate in the subsequent endometrial biopsy was 92.3%. Following the second‐line metronidazole/ciprofloxacin treatment, the overall cure rate was 99.1%. The live birth rate in the first ET cycle ( P =.031, RR 1.48, 95% CI 1.03‐2.12) and cumulative three ET cycles ( P =.037, RR 1.39, 95% CI 1.02‐1.90) following antibiotic treatment in the cured RIF/CE group (32.8% and 38.8%, respectively) was significantly higher than in the RIF/non‐CE group (22.1% and 27.9%, respectively). Conclusion Chronic endometritis was found in one‐third of infertile women with RIF. The oral antibiotic treatment against CE might be a promising therapeutic option for infertile women with RIF.