Premium
Immunological function of vitamin D during human pregnancy
Author(s) -
Ji JinLu,
Muyayalo Kahinho P.,
Zhang YongHong,
Hu XiaoHui,
Liao AiHua
Publication year - 2017
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12716
Subject(s) - pregnancy , vitamin d and neurology , immune system , decidua , preeclampsia , placenta , gestational diabetes , calcitriol receptor , vitamin d deficiency , vitamin , endocrinology , miscarriage , placental insufficiency , fetus , biology , medicine , immunology , gestation , genetics
The well‐established classic role of vitamin D is implicated in the regulation of the balance between calcium and phosphorus. Furthermore, vitamin D is also involved in many non‐classic physiological processes, mainly including the regulation of cell proliferation, differentiation, apoptosis and immune function, participation in the inflammatory response and maintenance of genome stability function. During pregnancy, vitamin D receptor and its metabolic enzymes are expressed at the placenta and decidua, indicating the potential role in the mechanism of immunomodulation at the maternal‐fetal interface. The insufficiency or deficiency of vitamin D may affect the mother directly and is related to specific pregnancy outcomes, such as preeclampsia, gestational diabetes, and recurrent miscarriage. This article reviews the effects of vitamin D on immune regulation during pregnancy.