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Abnormal ratio of CD 57 + cells to CD 56 + cells in women with recurrent implantation failure
Author(s) -
Jiang Ruiwei,
Yan Guijun,
Xing Jun,
Wang Zhilong,
Liu Yong,
Wu Hongyan,
Fan Xiangshan,
Zhou Jianjun,
Ding Lijun,
Sun Haixiang
Publication year - 2017
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12708
Subject(s) - endometrium , flow cytometry , foxp3 , immunocytochemistry , microbiology and biotechnology , medicine , andrology , endocrinology , chemistry , biology , immunology , immune system
Problem To define a more precise parameter for a better understanding of natural killer ( NK ) cells and its relation with regulatory T cells (Tregs) in women with recurrent implantation failure ( RIF ). Method of study The percentages of CD 56+ cells, CD 57+ cells and Foxp3+ cells in the endometrium and blood from 23 normal controls and 32 women with RIF were measured by immunocytochemistry and flow cytometry. Results Women with RIF had significantly increased ratio of CD 57+ cells to CD 56+ cells in both the endometrium ( P <.01) and blood ( P <.05), and decreased percentage of Foxp3+ cells in the endometrium ( P <.05). There was a significant negative correlation between CD 57+ cells to CD 56+ cells ratio and the percentage of Foxp3+ cells in the blood of RIF patients ( P <.05). Conclusion Our study provides a novel assessment parameter, CD 57+ cells to CD 56+ cells ratio, to evaluate NK cells and its relation with Tregs in RIF patients.