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Soluble CEACAM 1 and CEACAM 6 are differently expressed in blood serum of pregnant women during normal pregnancy
Author(s) -
Mach Pawel,
Gellhaus Alexandra,
Prager Sebastian,
Moore Tom,
Wennemuth Gunther,
Kimmig Rainer,
Köninger Angela,
Singer Bernhard B.
Publication year - 2017
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12700
Subject(s) - pregnancy , medicine , gestation , second trimester , immune system , third trimester , population , obstetrics , physiology , endocrinology , immunology , biology , genetics , environmental health
Problem CEACAM 1 and CEACAM 6 belong to the carcinoembryonic antigen ( CEA ) family and may play an immune‐modulatory role during pregnancy. The aim of the study was to determine the blood serum levels of soluble CEACAM 1 and CEACAM 6 over the course of pregnancy and postpartum. Method of study CEACAM 1 and CEACAM 6 levels were determined with customized in‐house Sandwich‐enzyme‐linked immunosorbent assay ( ELISA ) systems. The study population (n=125) was divided into four groups according to the pregnancy trimester and postpartum. Additionally, samples of non‐pregnant women (n=14) were analyzed. Results Serum levels of CEACAM 1 in healthy pregnant women were much lower than in non‐pregnant women, a difference not seen for CEACAM 6. Comparison between the trimesters and postpartum revealed a significant difference in CEACAM 1 serum levels. The highest CEACAM 1 levels were detected in third trimester. These levels were statistically significantly different from the CEACAM 1 levels in first trimester and second trimester. The lowest levels were observed in the second trimester. Postpartum CEACAM 1 serum concentrations were slightly lower than in the third trimester, but higher than in the first trimester and significantly higher compared to levels in the second trimester. Conclusion Decreased concentration of CEACAM 1 during the pregnancy suggests its regulatory role in the immune tolerance during the course of pregnancy.