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Assessment of the immunogenicity of gonadotrophins during controlled ovarian stimulation
Author(s) -
Morte Carles,
Celma Carles,
De Geyter Christian,
Urbancsek Janos,
Coroleu Lletget Buenaventura,
Cometti Barbara
Publication year - 2017
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12675
Subject(s) - immunogenicity , stimulation , in vitro fertilisation , antibody , hormone , hmg coa reductase , in vitro , menotropins , medicine , andrology , human fertilization , immune system , endocrinology , gonadotropin , follicle stimulating hormone , clinical study , ovulation induction , immunology , luteinizing hormone , biology , ovulation , pregnancy , biochemistry , anatomy , reductase , genetics , enzyme
Problem Gonadotrophin hormones are used for the controlled ovarian stimulation (COS) as part of the in vitro fertilization techniques. Therapeutic proteins have the potential to induce an unwanted immune response. Method of study The presence of anti‐FSH, anti‐LH and anti‐hCG antibodies were determined in patients from two different clinical trials after the repeated administration of hMG or FSH. Results In the first study, 27 subjects were screening for the presence of anti‐FSH antibodies. From the 27 patients, only one patient showed the presence of low levels of antibodies. In a second study, 25 patients were screened for the presence of anti‐FSH, anti‐LH and anti‐hCG antibodies. At the end of the study, no patients showed the presence of antibodies. Conclusion The results of this study suggest that repeated treatment cycles with FSH or hMG in patients undergoing COS for in vitro fertilization can be safely and effectively applied without concerns for immunogenicity.