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The female reproduction and senescence nexus
Author(s) -
Marquez Cielo Mae D.,
Ibana Joyce A.,
Velarde Michael C.
Publication year - 2017
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12646
Subject(s) - senescence , embryo , pregnancy , biology , phenotype , gestation , uterus , reproduction , microbiology and biotechnology , andrology , pathophysiology , physiology , endocrinology , medicine , genetics , gene
Successful pregnancy is regulated by several soluble factors that are differentially expressed throughout gestation. These factors are important to initiate and establish embryo implantation and parturition. Senescent cells, which undergo permanent cell proliferation arrest in response to stress, also produce several secreted factors, referred to as the senescence‐associated secretory phenotype ( SASP ). Here, we review some of the secreted factors found during early and late pregnancy and compare their expression profile with those of the SASP . Because senescent cells are found in the uterus and embryo during pregnancy, we hypothesize that SASP factors contribute to successful pregnancy. We discuss how senescent cells may support embryo development and signal parturition. We provide evidences for potential contribution of SASP to the physiology and pathophysiology of pregnancy.