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Is HLA ‐ E a possible genetic marker relevant for natural conception?
Author(s) -
Gelmini Georgia Fernanda,
Costa Cynthia Hernandes,
Nardi Fabiola da Silva,
Wowk Pryscilla Fanini,
Mattar Sibelle Botogosque,
Schuffner Alessandro,
Bicalho Maria da Graça,
Roxo Valéria Maria Munhoz Sperandio
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12587
Subject(s) - human leukocyte antigen , hla g , allele , context (archaeology) , genotype , biology , immunology , immune system , pregnancy , reproductive immunology , antigen , reproduction , genetics , gene , reproductive technology , lactation , paleontology
Background HLA ‐E products, class Ib human leukocyte antigens, act in the immunology of human reproduction as modulators of the maternal immune system during pregnancy. Aims To evaluate HLA ‐E role in the establishment of a viable pregnancy. Materials & Methods HLA ‐E was genotyped by sequence‐based typing ( SBT ) and analyzed for specific polymorphisms, comparing couples who underwent assisted reproduction treatment ( ART ) and fertile control couples. Results There was a significant difference in HLA ‐E allele and genotype distributions between ART couples and control couples. The allele HLA ‐E*01:03 was observed in 63.2% of ART men and in 35.1% of fertile men ( P = 0.0032). Conclusion These results suggest that HLA ‐E allelic variants may play a role in the modulation of immune responses in the context of the inability of natural conception and establishment of a viable pregnancy.