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Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage
Author(s) -
Chen Xian,
Yin Biao,
Lian RuoChun,
Zhang Tao,
Zhang HongZhan,
Diao LiangHui,
Li YuYe,
Huang ChunYu,
Liang DeSheng,
Zeng Yong
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12585
Subject(s) - vitamin d and neurology , immune system , medicine , recurrent miscarriage , endocrinology , vitamin , immunity , immunology , t cell , cellular immunity , cd19 , peripheral blood , cytotoxicity , biology , miscarriage , pregnancy , biochemistry , in vitro , genetics
Problem We aimed to investigate the modulatory effects of vitamin D on peripheral blood cellular immune response in patients with recurrent miscarriage ( RM ). Method of study The effect of vitamin D on the number of peripheral blood cells, T helper 1 (Th1) cytokines, and NK cytotoxicity was measured in 99 women with RM . Results The percentage of CD 19 + B cells and NK cytotoxicity at an effector‐to‐target cell (E:T) ratio of 50:1, 25:1, and 12.5:1 were significantly higher in the vitamin D insufficiency group ( VDI ) than in the vitamin D normal group ( VDN ) ( P <.05 each). The proportion of TNF ‐α‐expressing Th cells was significantly higher in the vitamin D deficiency group ( VDD ) than in VDN ( P <.05). However, there were no significant differences between VDI and VDD . This dysregulation was significantly reduced with 1,25( OH ) 2 D supplementation. Conclusion The data suggest that the abnormalities of cellular immune response were observed in RM patients with a low vitamin D level, which could be regulated to some extent with 1,25( OH ) 2 D supplementation.