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Combined treatment of prednisone and aspirin, starting before ovulation induction, may improve reproductive outcomes in ANA ‐positive patients
Author(s) -
Fan Jiao,
Zhong Yiping,
Chen Cuina
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12559
Subject(s) - medicine , prednisone , anti nuclear antibody , aspirin , ovulation induction , ovulation , in vitro fertilisation , pregnancy rate , randomized controlled trial , pregnancy , gynecology , abortion , antibody , immunology , autoantibody , biology , hormone , genetics
Labeled problem Antinuclear antibody (ANA) could cause reproductive failure. But treatment for women with antinuclear antibody was controversial. Methods One hundred and thirty‐three ANA + women with one‐time in vitro fertilization (IVF) implantation failure were divided into two groups randomly. The study group comprised 60 sero‐positive for antinuclear antibody. These patients were treated with prednisone (10 mg/day) and aspirin (100 mg/day) starting 3 months before induction of ovulation in 60 IVF cycles. Seventy‐three patients were included in untreated group. Results Fertilization rate, pregnancy rate, and implantation rate were significantly higher in treatment group, while abortion rate was markedly higher in non‐treatment group by randomized controlled trial. Same conclusions were also proved between cycles of 60 ANA + women with therapy and their former cycles without any treatment. Conclusion Combined treatment of prednisone for immunosuppression and aspirin as an antithrombotic agent, starting 3 months before ovulation induction, may improve reproductive outcomes in ANA + patients.