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Protective effect of polysaccharides from Lycium barbarum on spermatogenesis of mice with impaired reproduction system induced by cyclophosphamide
Author(s) -
Qian Li,
Yu Sijiu
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12558
Subject(s) - cyclophosphamide , spermatogenesis , lycium , reproduction , sperm , superoxide dismutase , polysaccharide , andrology , malondialdehyde , biology , reproductive system , endocrinology , medicine , chemotherapy , biochemistry , oxidative stress , pathology , ecology , alternative medicine
Problem Lycium barbarum ( L. barbarum ) polysaccharides ( LBP s) are the main bioactive component. However, effect of LBP on spermatogenesis of mice with impaired reproduction system induced by cyclophosphamide is undetermined. Method of study This study aims to investigate the effect of LBP on spermatogenesis of rats with impaired reproduction system induced by cyclophosphamide. Kunming mice were randomly divided into five groups as follows: normal control group, model group (treated with cyclophosphamide) and three LBP groups (treated with cyclophosphamide and 0.2, 0.4 and 0.6 g/kg LBP s, respectively). Results Results indicate that LBP treatment improved sperm density, sperm movement, the rate of normal sperm morphology, and protein expression and superoxide dismutase activity in the testes of the mice and decreased the nitrate nitrogen level in the testes of the mice. Conclusion LBP s have obviously protective effect on the spermatogenesis of rats with impaired reproduction system induced by cyclophosphamide.