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Levels of CD 40L and other inflammatory biomarkers in obese and non‐obese women with polycystic ovary syndrome
Author(s) -
Sarray Sameh,
Almawi Wassim Y.
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12549
Subject(s) - polycystic ovary , medicine , ovary , endocrinology , obesity , insulin resistance
Problem We investigated whether changes in sCD 40L, hs‐ CRP , IL ‐6, and TNF ‐α levels are associated with polycystic ovary syndrome ( PCOS ). Method of study Case–control study involving 143 women with and 165 women without PCOS . Result(s): Reduced sCD 40L, and increased hs‐ CRP and IL ‐6, but not TNF ‐α, levels were seen between cases and controls. ROC analysis demonstrated high sensitivity and specificity for sCD 40L and hs‐ CRP as PCOS predictors. Altered sCD 40L levels were associated with PCOS , irrespective of body weight. Significant differences in IL ‐6 levels were seen between non‐obese subjects and for TNF ‐α in obese subjects. sCD 40L correlated negatively with age, insulin, HOMA ‐ IR , LH , free testosterone, FAI , and hirsutism, but positively with SHBG . CRP correlated positively with BMI , insulin, HOMA ‐ IR , free testosterone, and hirsutism. IL ‐6 correlated positively with hirsutism. TNF ‐α correlated positively with age, but negatively with insulin and HOMA‐IR. Conclusion CD 40L, more than IL ‐6, or TNF ‐α, constitutes a predictor to explain PCOS and associated features.